Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque.

"Competing interests Bao-jian Li and Frank Y Xie are consultants for and Du Cheng is an employee of Guangzhou Top Genomics, Ltd. Qingquan Tang, Frank Y. Xie, Yijia Liu, Martin C. Woodle and Patrick Y. Liu are employees of Intradigm Corporation. Both Top Genomics, Ltd. and Intradigm Corporation are biopharmaceutical companies that are developing RNAi therapeutics for the treatment of human disease."

"This study was supported in part by the Science and Technology Commission, Guangdong Provincial Government, Guangzhou Science and Technology Bureau, Guangzhou Economic & Technological Development District, and China World Trade Corporation (Guangzhou), Top Biotech, Ltd. (Hong Kong), China. We thank C. Lu, X.S. Zhang and D.C. Zheng of Top Genomics, Ltd. (Guangzhou) for their administrative work to coordinate and facilitate the study; H. Gao, X.M. Tu, L.L. Bao, W. Deng and B.L. Zhang of Institute of Laboratory Animal Science and L. Ruan of Institute of Virology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, for their supports during the study; W. Tian and E. Lader of Qiagen for their collaborative efforts; Y.Y. Gu of Guangzhou Institute of Respiratory Diseases for her advice on lung pathological analysis; and ONY Inc. Amherst, New York, USA for providing Infasurf."