HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors.
Journal Information
Full Title: AIDS Res Ther
Abbreviation: AIDS Res Ther
Country: Unknown
Publisher: Unknown
Language: N/A
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Subject Category: Acquired Immunodeficiency Syndrome
Available in Europe PMC: Yes
Available in PMC: Yes
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"Competing interests The author(s) declare that they have no competing interests."
"AcknowledgementsThe authors wish to thank W. C. Drosopoulos for reading the manuscript, R. A. Bambara for providing the plasmids for generating T7 RNA transcripts used in RNase H assay and the late Dr. Reaching Lee for providing the purified E478Q mutant RT. Research described in this report was supported by a Public Service grant to VRP (NIH RO1 AI30861). TSF acknowledges support from an institutional pre-doctoral training grant (NIH T32 GM07491)."
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Last Updated: Aug 05, 2025