Effects of switching between anti-TNF therapies on HAQ response in patients who do not respond to their first anti-TNF drug.

"Disclosure statement : The authors have declared no conflicts of interest."

"Funding : The BSRBR was established primarily to investigate the safety of biologic agents in routine practice. The financial support to the BSRBR comes indirectly from the following UK companies marketing biologic agents in the UK: Schering-Plough, Wyeth Laboratories, Abbott Laboratories and Amgen. The resources used to fund the BSRBR are received under contract by the BSR, which then provides a research grant under a separate contract to the University of Manchester, allowing the investigators normal academic freedom in relation to the data, their analysis and use. Under the terms of the contract between the BSR and the pharmaceutical companies, all publications are sent in advance to the companies prior to submission, for the purposes of information. The companies can, if they wish, point out factual errors. Any comments are vetted by three members of the BSRBR Scientific Steering Committee, who decide whether they should be passed on to the authors. All publications are also reviewed by the BSR, but the material presented and the views expressed in all publications from the BSRBR are those of the authors and do not necessarily represent the views of the BSR. Funding to pay the Open Access publication charges for this article was provided by a grant from the British Society for Rheumatology."