The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.

"This work was supported by grant CA76641 from the National Cancer Institute, National Institutes of Health, grants from St. Baldrick's Foundation, Leukemia Research Life (Detroit) and from the Sehn Family Foundation, the Dale Meyer Memorial Endowment for Leukemia Research, and the Ring Screw Textron Chair in Pediatric Cancer Research. Ms. Gedman is supported by NIH training grant T32-CA009531. Dr. Taub is a Scholar in Clinical Research of the Leukemia and Lymphoma Society. We thank the Children's Oncology Group ALL Biology Subcommittee for providing the clinical specimens and clinical data that made this study possible. The experimental insight and advice of Dr. Zhanjun Hou (Karmanos Cancer Institute) with the NOTCH1 and FBW7 mutagenesis is greatly appreciated. Finally, we would like to thank Dr. Spyros Artavanis-Tsakonas (Harvard University, Cambridge, MA) for providing wild type NOTCH1 in pcDNA3 and Dr. Lucio Miele (Loyola University, Chicago, IL) for the gift of ICN1 in pcDNA3."