Activation in brain energy regulation and reward centers by food cues varies with choice of visual stimulus.

"This work was supported by NIH grant K23 DK070826-01 (PI: Schur). We also acknowledge the donation of a number of photographs used for this study by Great American Stock (Brookfield, WI). We thank our participants for their contribution and the twins in the University of Washington Twin Registry for their dedication."

"fMRI data analyses were performed by using the Oxford Centre for Functional MRI of the Brain (FMRIB) Software Library version 3.3 (FSL; http://www.fmrib.ox.ac.uk/fsl/). The following preprocessing steps were applied: 1) motion correction was conducted with Motion Correction using FMRIB's Linear Image Registration Tool (MCFLIRT); 2) nonbrain structures were removed by using the Brain Extraction Tool; and 3) data were spatially smoothed by using a Gaussian kernel of full width at half maximum = 5 mm and temporally smoothed with a high-pass filter of sigma = 72 s. Time series statistical analyses were carried out by using FMRIB's Improved Linear Model with local autocorrelation correction. Condition effects were estimated at each voxel for the following contrasts: 1) fattening food > object; 2) non-fattening food > object; 3) all food > object; 4) fattening food > non-fattening food; 5) non-fattening food > fattening food; and 6) object > all food. The “all food” category was created by combining all images obtained during viewing of fattening food and non-fattening food blocks into one condition (fattening food + non-fattening food). Individual fMRI data were registered to the high-resolution scan by using fieldmap corrections, warped with an affine transformation to the MNI152 standard image by using FMRIB's Linear Image Registration Tool, and resampled to 2 mm voxels."