Developmental and degenerative features in a complicated spastic paraplegia.

"Potential Conflicts of Interest Nothing to report."

"This work was supported by the NINDS (grant RO1 NS 35129, C.A.W.), NICHD (grant RO1 HD029178, A.-S.L.), the Dubai Harvard Foundation for Medical Research (C.A.W.), the Manton Center for Orphan Disease Research (C.A.W.), the Muscular Dystrophy Association (Development Grant, M.C.M.), and the University of North Carolina (Reynolds Faculty Fellowship, A.-S.L.). C.A.W. is an Investigator of the Howard Hughes Medical Institute. We thank the families for their cooperation and their hospitality; the local nurses and doctors for their assistance; Megumi Aita at the University of North Carolina In Situ Core for help with the in situ analysis; Daniel Rakiec at Children's Hospital, Boston for help with the sample preparation and analysis; and the following colleagues at Children's Hospital Boston for helpful discussion on the clinical features of the patients: Hope E. Dickinson, a speech pathologist from the Department of Otolaryngology and Communication Enhancement, and Janice Ware, a child psychologist and associate director of the Developmental Medicine Center."