Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.

"This work was funded by a Royal Society project grant RG080077 and a Biotechnology and Biological Sciences Research Council grant BB/H001085/1. DKC is a Leverhulme Early Career Fellow. FM is funded by a Tenovus PhD studentship. JJM is a National Health and Medical Research Council (NHMRC) Biomedical Fellow supported by a Welsh Office of Research and Development (WORD) Research Funding Scheme. We thank Scott R. Burrows, Queensland Institute of Medical Research, Brisbane, for the donation of the T2 cell line. The authors declare no conflict of financial interests."

"This work was funded by a Royal Society project grant RG080077 and a Biotechnology and Biological Sciences Research Council grant BB/H001085/1. DKC is a Leverhulme Early Career Fellow. FM is funded by a Tenovus PhD studentship. JJM is a National Health and Medical Research Council (NHMRC) Biomedical Fellow supported by a Welsh Office of Research and Development (WORD) Research Funding Scheme. We thank Scott R. Burrows, Queensland Institute of Medical Research, Brisbane, for the donation of the T2 cell line. The authors declare no conflict of financial interests."