Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei.

"we began our investigations based on the first x-ray crystal structures of falcipain-2 available since 2006 (protein data bank (pdb) codes: 1yvb 2ghu 3bpf) - and of rhodesain published only recently in 2009 and 2010 (pdb codes: 2p7u 2p86) both falcipain-2 and rhodesain share the common features of clan ca cysteine proteases with the classical papain fold consisting of two distinct domains."

"<~ErrTag=I>V.E. is grateful for a Kekulé fellowship from the German Fonds der Chemischen Industrie. Financial support by the Deutsche Forschungsgemeinschaft (DFG, SFB 630, TP A4 to T.S.) and the Swiss National Science Foundation is gratefully acknowledged. We thank Jennifer Rath and Svetlana Sologub for performing the Trypanosoma brucei brucei and macrophages assays, Dr. Daniel Bur (Actelion Pharmaceuticals Ltd.) for helpful discussions, and Dr. Valentina Aureggi and Laura Salonen for reviewing the manuscript.<~ErrTag=/I> "