Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.

"Disclosure statement The authors declare that they have no actual or potential conflicts of interest. Mice were housed in controlled conditions in accordance with guidance issued by the Medical Research Council in Responsibility in the Use of Animals for Medical Research (1993) and all experiments were carried out under License from the UK Home Office and with Local Ethical Review panel approval."

"We thank Ray Young for help with preparation of the figures, Kate Alford (NIMR, London) for assistance with Tc1 and control samples, and Wendy Noble (Kings College, London) and Selina Wray (University College, London) for helpful discussion. We thank Catherine O'Malley and Caroline Powell for technical assistance. We also thank Drs. P. Davies (Einstein College, New York) and S.M. Dilworth (Imperial College, London) for antibodies. V.L.J.T. is funded by the UK Medical Research Council (programme number U117527252), the AnEUploidy grant from Framework Programme 6 from the European Union Commission, and the Wellcome Trust; F.K.W., O.S., and E.M.C.F. are funded by the UK Medical Research Council, the Wellcome Trust, the AnEUploidy grant from Framework Programme 6 from the European Union Commission and the Fidelity Foundation. These funding bodies had no role in the design of this study or the decision to publish these data."