Assessment of the cardiac safety of prucalopride in healthy volunteers: a randomized, double-blind, placebo- and positive-controlled thorough QT study.

"Competing Interests Boaz Mendzelevski, MD (employed by CoreLab Partners) and Patricia Robinson are consulting for Shire-Movetis NV. There is no other financial information to disclose. Dennis Chanter, DPhil is contracted by CoreLab Partners. There is no other financial information to disclose. John Camm, MD is an advisor to Shire-Movetis NV regarding drug-induced QT effects. Jannie Ausma, Rene Kerstens and Lieve Vandeplassche are employees of Shire-Movetis NV. There is no other financial information to disclose."

"Medical writing support in the preparation of the manuscript was provided by Delia Randall and Victoria Harvey and was funded by Shire-Movetis NV. The authors would also like to thank Joanne Zhang, PhD, of the Office of Biostatistics, CDER, FDA, for her original contribution to the nested crossover design for assay sensitivity assessment in parallel group thorough QT studies, on which this study design is based."