Alzheimer's risk variants in the clusterin gene are associated with alternative splicing.

"in our experiments using brain rna we did not observe the transcript lacking exon 2 described in a breast cancer cell line but we found a transcript reported in the ucsc genome browser (genbank acc# cr617497) lacking exons1 3 and 4 thus missing both the endoplasmic reticulum-targeting signal and nuclear localization signal."

"The authors declare no conflicts of interest."

"We thank Dr Francine Benes of the Harvard Brain Tissue resource center and Dr Juan Troncoso of the Johns Hopkins Brain Resource Center for providing brain tissue. We thank Dr Andrew McCallion for conversations, advice and expertise in multiple aspects of the project and Dr David Valle and Mariela Zeledon for providing mouse primary cortical neurons. This work was supported by NIA grants to DA and SSB (RO1AG022099 and RO1AG021804) and an award from the Neurosciences Education and Research Foundation to DA."