Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study.

"Declaration of personal interests : Michael Kamm has served as a speaker, a consultant and an advisory board member for Shire-Movetis, and has received previous research funding from Janssen. Anton Emmanuel has served as a speaker and an advisory board member for Shire, Takeda, GSK, Mundipharma, Coloplast. René Kerstens and Lieve Vandeplassche are employees of Shire-Movetis. The writing and preparation of this article was performed by the authors (Michael A Kamm and Anton V Emmanuel) without payment, but preparation was undertaken with the assistance of Shire-Movetis. Declaration of funding interests : This study was funded in part by Janssen. Technical support in the formatting, preparation of relevant submission details and materials, and submission of this paper was performed by Kerri Bridgwater and funded by Shire-Movetis."

"The study was approved by the Northwick Park and St Mark's Ethics Committee. All subjects gave written informed consent to participate in the study. Trial registration number: ClinicalTrials.gov NCT007 93247."