Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

Authors:
Wacker SJ; Jurkowski W; Simmons KJ; Fishwick CW; Johnson AP and 4 more

Journal:
ChemMedChem

Publication Year: 2012

DOI:
10.1002/cmdc.201100600

PMCID:
PMC3525944

PMID:
22473914

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Journal Information

Full Title: ChemMedChem

Abbreviation: ChemMedChem

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Pharmacology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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"The authors thank Dr. Basil Hartzoulakis and Dr. Marc Rogers for their assistance in computational chemistry and automated patch clamp assay development, respectively, and Dr. Michael Bale for generation of the CHO-K1 Kv1.1–1.2(3) cell line. This research received funding from the European Community’s Seventh Framework Program FP7/2007-2013 under grant agreement no. HEALTH-F4-2007-201924, EDICT Consortium."

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