The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features.

"Disclosure statement None of the authors have potential or actual conflicts of interest, and all the authors have seen the manuscript before submission. The work was funded by the Reta Lila Weston Foundation, the PSP Brain Bank, USA Parkinson's Disease Foundation and the MRC/Wellcome Trust through a PD Centre Grant, and by the Wellcome Trust. The funding source had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There is no animal work in the manuscript, and the human work on blood and pathology materials has been carried out in compliance with UK regulations."

"The authors thank the NHLBI GO Exome Sequencing Project and its ongoing studies that produced and provided exome variant calls for comparison: the Lung GO Sequencing Project (HL-102923), the WHI Sequencing Project (HL-102924), the Broad GO Sequencing Project (HL-102925), the Seattle GO Sequencing Project (HL-102926), and the Heart GO Sequencing Project (HL-103010). The authors also thank the NIEHS Environmental Genome Project for supporting this project under contract no. HHSN273200800010C. J.D.W. is supported by a Wellcome Senior Clinical Fellowship (091673/Z/10/Z). The work was funded by the Reta Lila Weston Foundation, the PSP Brain Bank (A.J.L., T.R., J.Holton), USA Parkinson's Disease Foundation (G.X., H.H.), the Medical Research Council (MRC)/Wellcome Trust (WT) through a PD Centre Grant (J.H., A.J.L.), by the Wellcome Trust (H.H.), the MRC (J.H., H.H.) and The National Institute for Health Research (NIHR) UCLH/UCL Comprehensive Biomedical Research Centre. We also thank Linda Parsons for the preparation of the human brain tissue, Robert Courtney and Catherine Strand for immunohistochemistry staining, and Susan Stoneham, Iliyanna Komsiyska, and June Smalley for administrative assistance. The work was funded by the Reta Lila Weston Foundation, the PSP Brain Bank, USA Parkinson's Disease Foundation and the MRC/Wellcome Trust through a PD Centre Grant, and by the Wellcome Trust. The funding source had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."