Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS.

"Declaration of personal interests : Dr Filippo Cremonini has no personal or funding interests to declare. Dr Anthony Lembo has served as a consultant and advisor for Prometheus Laboratories Inc, GlaxoSmithKline, Ironwood Pharmaceuticals, Inc., Forest Research Institute, Inc., Salix Pharmaceuticals, Inc. and Alkermes plc. Dr Jean Paul Nicandro, Dr Reshma Shringarpure and Dr Emil Chuang are employees of Prometheus Laboratories Inc. Veronika Atkinson is a former employee of Prometheus Laboratories Inc. Declaration of funding interests : This study was funded in full by GlaxoSmithKline and Prometheus Laboratories Inc. The writing of this paper was funded in full by Prometheus Laboratories Inc. Initial data analyses were undertaken by Amy Heath, Vanessa Ameen, Marquita West and Susan Gordon, who at the time were employees of GlaxoSmithKline. Funding for these analyses was provided by GlaxoSmithKline. Writing support was provided by Dr Patrice Ferriola of KZE PharmAssociates, LLC, and Dr Rebecca Watson and Dr Anthony Stonehouse of Watson & Stonehouse Enterprises, LLC. Writing support was funded in full by Prometheus Laboratories Inc."

"Declaration of personal interests: Dr Filippo Cremonini has no personal or funding interests to declare. Dr Anthony Lembo has served as a consultant and advisor for Prometheus Laboratories Inc, GlaxoSmithKline, Ironwood Pharmaceuticals, Inc., Forest Research Institute, Inc., Salix Pharmaceuticals, Inc. and Alkermes plc. Dr Jean Paul Nicandro, Dr Reshma Shringarpure and Dr Emil Chuang are employees of Prometheus Laboratories Inc. Veronika Atkinson is a former employee of Prometheus Laboratories Inc. Declaration of funding interests: This study was funded in full by GlaxoSmithKline and Prometheus Laboratories Inc. The writing of this paper was funded in full by Prometheus Laboratories Inc. Initial data analyses were undertaken by Amy Heath, Vanessa Ameen, Marquita West and Susan Gordon, who at the time were employees of GlaxoSmithKline. Funding for these analyses was provided by GlaxoSmithKline. Writing support was provided by Dr Patrice Ferriola of KZE PharmAssociates, LLC, and Dr Rebecca Watson and Dr Anthony Stonehouse of Watson & Stonehouse Enterprises, LLC. Writing support was funded in full by Prometheus Laboratories Inc."

"Patients were enrolled from June 2003 to June 2005 at multiple study sites in the United States. Institutional Review Boards at each individual site approved the protocol. Patients provided written informed consent upon study entry. The efficacy data of alosetron on IBS symptom relief from this study have been previously reported. Details of the clinical trial are publicly accessible at clinicaltrials.gov, registration number: NCT00067561."