Incremental Reduction in Risk of Death Associated With Use of Guideline-Recommended Therapies in Patients With Heart Failure: A Nested Case-Control Analysis of IMPROVE HF.

"Disclosures Dr Gregg C. Fonarow, research grants: National Institutes of Health (significant); consultant: Medtronic (modest), Novartis (significant); honoraria: Medtronic (modest). Dr Nancy Albert, no relationships to disclose. Dr Anne B. Curtis, research grants: Medtronic (significant); Speakers Bureau: Medtronic (modest), Sanofi-Aventis (significant); honoraria: Medtronic (modest); consultant/advisory board: Sanofi-Aventis (significant), St Jude Medical (modest), Biosense Webster (modest), Janssen Pharmaceuticals (modest); fellowship support: Medtronic (significant). Dr Mihai Gheorghiade, consultant: Abbott Laboratories (modest), Astellas (modest), AstraZeneca (modest), Bayer Schering Pharma AG (significant), Cytokinetics, Inc (modest), DebioPharm SA (significant), Errekappa Terapeutici (Milan, Italy) (modest), GlaxoSmithKline (modest), Johnson & Johnson (modest), Medtronic (significant), Merck (modest), Novartis Pharma AG (significant), Otsuka Pharmaceuticals (significant), Pericor Therapeutics (significant), Protein Design Laboratories (modest), Sanofi-Aventis (modest), Sigma Tau (significant), Solvay Pharmaceuticals (significant); expert witness: Johnson & Johnson (modest). Yang Liu, employee of Medtronic, Inc. Dr Mandeep R. Mehra, research grant: National Institutes of Health/NHLBI (significant); honoraria: Geron, Medtronic, St Jude Medical (modest); consultant/advisory board: Johnson & Johnson (modest), St Jude Medical (modest); institution/employer: University of Maryland (significant). Dr Christopher M. O'Connor, research grant: Johnson & Johnson, Medtronic, GE Healthcare, Gilead, Roche Diagnostics, Critical Diagnostics, BG Medicine, Otsuka, Acorn (significant); consultant/advisory board: Merck, Medtronic, GE Healthcare, Amgen, Medpace, Roche, Actelion, Novella, Trevena, Martek Biosciences, Pfizer, Nile, Novartis, Heartware, Hoffman LaRoche, Ikaria, ResMed (significant). Dr Dwight Reynolds, research grants: Medtronic, Biotronik (significant); speakers bureau: Medtronic, Sorin (significant); honoraria: Medtronic, Sorin, St Jude Medical (significant); consultant/advisory board: Medtronic, Sorin (modest). Dr Mary Norine Walsh, consultant: Medtronic (modest), United HealthCare (modest). Dr Clyde W. Yancy, no relationships to disclose."

"Sources of Funding IMPROVE HF is supported by Medtronic, Inc, Minneapolis, MN."