Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).

"thus although there is currently no ace moexiprilat co-crystal structure available inspection of co-crystal structures for closely related 'pril' family ace inhibitors such as enalaprilat (pdb: 1uze ) suggests that ace inhibition should show strong dependence on the absolute ( s )-configuration for the moexipril(at) tetrahydroisoquinoline core."

"We thank M.J. Lohse for allowing us to use the Epac1-camps cAMP probe and A.K. Doak for assistance with aggregator controls. This work was supported by an MRC grant to GSB (MR/J007412/1) and by US National Institute of Health grant GM71896 to BKS, National Research Service Award-Kirschstein fellowships F32GM096544 (to RGC), and US National Institutes of Health grants GM59957 and GM71630 (to BKS). RTC is supported by BBSRC."