Dolutegravir in antiretroviral-naive adults with HIV-1: 96-week results from a randomized dose-ranging study.

"Conflicts of interest This work was supported by ViiV Healthcare. H.-J.S. has received consulting fees or honorarium from Pfizer, ViiV Healthcare, and GlaxoSmithKline; has been provided support for travel to meetings for the study or other purposes from GlaxoSmithKline and ViiV Healthcare; has had writing support from ViiV Healthcare; has been provided documentation fees for clinical trial documentation from GlaxoSmithKline; has been an advisory board member for Abbott, Gilead Sciences, ViiV Healthcare, Boehringer-Ingelheim, Merck Sharp & Dohme, and Janssen-Cilag; has been a consultant for Gilead Sciences, ViiV Healthcare, Bristol-Myers Squibb, Merck Sharp & Dohme, Janssen-Cilag, and Boehringer-Ingelheim; has provided expert testimony for Bristol-Myers Squibb; has received payment for lectures including service on speakers bureaus from Abbott, Bristol-Myers Squibb, ViiV Healthcare, Gilead Sciences, Janssen-Cilag, and Boehringer-Ingelheim; and has received payment for development of educational presentations from Bristol-Myers Squibb, Janssen-Cilag, and ViiV Healthcare. J.R. has received an educational grant from GlaxoSmithKline and ViiV Healthcare; has board membership with Abbott, Astellas, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, Tibotec-Janssen, and ViiV Healthcare; is employed by the University of Montpellier and the Hospital of Montpellier; has grants/grants pending from the French National Agency for Research on AIDS and viral hepatitis (ANRS); has received payment for lectures including service on speakers bureaus for Abbott, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, Tibotec, and ViiV Healthcare; and has been provided travel/accommodations/meeting expenses from Abbott, Astellas, Boehringer-Ingelheim, Bristol-Myers Squibb, Merck Sharp & Dohme, Tibotec-Janssen, and ViiV Healthcare. A.L. has been an advisor and speaker for Abbott, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, ViiV Healthcare, Pfizer, Roche, GlaxoSmithKline, and Janssen-Cilag; and has participated as principal investigator for several trials sponsored by Abbott, Bristol-Myers Squibb, Pfizer, Merck Sharp & Dohme, Tibotec, Roche, ViiV Healthcare, and GlaxoSmithKline. E.V. has no conflicts of interest to disclose. F.P. has received grants from GlaxoSmithKline; has fulfilled board membership for Abbott, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck Sharp & Dohme, and ViiV Healthcare; and has received payment for lectures including service on speakers bureaus from Abbott, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck Sharp & Dohme, and ViiV Healthcare. F.F. has grants/grants pending from ViiV Healthcare, Abbott, Boehringer-Ingelheim, Gilead Sciences, Janssen, and Vertex; and has received payment for lectures including service on speakers bureaus from Janssen, Merck Sharp & Dohme, and ViiV Healthcare. S.A., M.S., N.F., and S.M. are employees of GlaxoSmithKline and as a result receive stock options and support for travel to study-related meetings. The SPRING-1 Team included the following investigators: J.R., I. Cotte, F. Raffi, C. Katlama, P. Yeni, J-M. Molina, J. van Lunzen, H-J.S., M. Stoll, T. Lutz, G. Carosi, F. Maggiolo, G. Rizzardinin, A. Lazzarin, O Tsybakova, E Voronin, A Rakhmanova, F Pulido, J Arribas, S Moreno-Guillen, J Gatell, B. Lotet, E. DeJesus, F. Felizarta, T. Hawkins, J. Lalezari, I. McCurdy, G. Rischmond, S. Schneider, L. Sloan, J. Torres, B. Young, T. Vanig, and M. Mustafa."

"Conflicts of interestThis work was supported by ViiV Healthcare.H.-J.S. has received consulting fees or honorarium from Pfizer, ViiV Healthcare, and GlaxoSmithKline; has been provided support for travel to meetings for the study or other purposes from GlaxoSmithKline and ViiV Healthcare; has had writing support from ViiV Healthcare; has been provided documentation fees for clinical trial documentation from GlaxoSmithKline; has been an advisory board member for Abbott, Gilead Sciences, ViiV Healthcare, Boehringer-Ingelheim, Merck Sharp & Dohme, and Janssen-Cilag; has been a consultant for Gilead Sciences, ViiV Healthcare, Bristol-Myers Squibb, Merck Sharp & Dohme, Janssen-Cilag, and Boehringer-Ingelheim; has provided expert testimony for Bristol-Myers Squibb; has received payment for lectures including service on speakers bureaus from Abbott, Bristol-Myers Squibb, ViiV Healthcare, Gilead Sciences, Janssen-Cilag, and Boehringer-Ingelheim; and has received payment for development of educational presentations from Bristol-Myers Squibb, Janssen-Cilag, and ViiV Healthcare.J.R. has received an educational grant from GlaxoSmithKline and ViiV Healthcare; has board membership with Abbott, Astellas, Boehringer-Ingelheim, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, Tibotec-Janssen, and ViiV Healthcare; is employed by the University of Montpellier and the Hospital of Montpellier; has grants/grants pending from the French National Agency for Research on AIDS and viral hepatitis (ANRS); has received payment for lectures including service on speakers bureaus for Abbott, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, Tibotec, and ViiV Healthcare; and has been provided travel/accommodations/meeting expenses from Abbott, Astellas, Boehringer-Ingelheim, Bristol-Myers Squibb, Merck Sharp & Dohme, Tibotec-Janssen, and ViiV Healthcare.A.L. has been an advisor and speaker for Abbott, Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, ViiV Healthcare, Pfizer, Roche, GlaxoSmithKline, and Janssen-Cilag; and has participated as principal investigator for several trials sponsored by Abbott, Bristol-Myers Squibb, Pfizer, Merck Sharp & Dohme, Tibotec, Roche, ViiV Healthcare, and GlaxoSmithKline.E.V. has no conflicts of interest to disclose.F.P. has received grants from GlaxoSmithKline; has fulfilled board membership for Abbott, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck Sharp & Dohme, and ViiV Healthcare; and has received payment for lectures including service on speakers bureaus from Abbott, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck Sharp & Dohme, and ViiV Healthcare.F.F. has grants/grants pending from ViiV Healthcare, Abbott, Boehringer-Ingelheim, Gilead Sciences, Janssen, and Vertex; and has received payment for lectures including service on speakers bureaus from Janssen, Merck Sharp & Dohme, and ViiV Healthcare.S.A., M.S., N.F., and S.M. are employees of GlaxoSmithKline and as a result receive stock options and support for travel to study-related meetings.The SPRING-1 Team included the following investigators: J.R., I. Cotte, F. Raffi, C. Katlama, P. Yeni, J-M. Molina, J. van Lunzen, H-J.S., M. Stoll, T. Lutz, G. Carosi, F. Maggiolo, G. Rizzardinin, A. Lazzarin, O Tsybakova, E Voronin, A Rakhmanova, F Pulido, J Arribas, S Moreno-Guillen, J Gatell, B. Lotet, E. DeJesus, F. Felizarta, T. Hawkins, J. Lalezari, I. McCurdy, G. Rischmond, S. Schneider, L. Sloan, J. Torres, B. Young, T. Vanig, and M. Mustafa. This work was supported by ViiV Healthcare. F.P. has received grants from GlaxoSmithKline; has fulfilled board membership for Abbott, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck Sharp & Dohme, and ViiV Healthcare; and has received payment for lectures including service on speakers bureaus from Abbott, Bristol-Myers Squibb, Gilead Sciences, Janssen, Merck Sharp & Dohme, and ViiV Healthcare."