IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms.

"This study was supported by the National Institutes of Health Grants R01 DK084082 (to L.E.H.) and the National Multiple Sclerosis Society Award CA-1059-A-13 and the UAB Collaborative MS Research Center (W.Y.). We wish to thank the other members of the Harrington laboratory, as well as the Zajac laboratory, for helpful discussions and critical reading of this manuscript. We also wish to thank Dr. Chander Raman for providing the B6.STAT1−/− mice to us, Dr. Xiangqin Cui for assistance with statistics of real-time PCR data, Katie Alexander and the Elson laboratory for assistance with SFB PCR, and Enid Keyser of the UAB Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center Cytometry Facility and Marion Spell of the UAB Center for AIDS Research Flow Cytometry Core for cell sorting."