Ex vivo lung perfusion to improve donor lung function and increase the number of organs available for transplantation.

"Conflicts of interest The authors of this manuscript have no conflict of interest to disclose."

"Funding This study was funded by Fondazione IRCCS Ca’ Granda–Ospedale Maggiore Policlinico, Milano, Italy, and by Regione Lombardia. A contribution was also provided by Lega Lombarda Fibrosi Cistica."

"The clinical outcome of subjects receiving EVLP lungs was compared to that of recipients undergoing standard transplantation (Standard) within the same time frame. At the time of listing, potential recipients were asked to sign an informed consent regarding the possibility of receiving EVLP-treated lungs. At the end of the EVLP procedure, if lungs were deemed suitable for transplantation, subjects were informed that they were receiving reconditioned lungs and were asked for a second consent. The investigation was approved by the Ethics Committee of our Institution (3307/2011) and is registered at ClinicalTrials.gov (Identifier: NCT01967953)."