Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene.

"Dr E. Jaros has been supported by the UK NIHR Biomedical Research Centre for Ageing and Age‐Related Disease award to the Newcastle upon Tyne Hospitals NHS Foundation Trust. D.M.A.M. and S.P.‐B. also receive funding from MRC and Wellcome Trust which supported this study in part. Tissue for this study was provided partly by the Newcastle Brain Tissue Resource (NBTR) which is funded in part by a grant from the UK Medical Research Council (G0400074, G1100540), by the Newcastle NIHR Biomedical Research Centre in Ageing and Age Related Diseases award to the Newcastle upon Tyne Hospitals NHS Foundation Trust, and by a grant from the Alzheimer's Society and Alzheimer's Research UK, as part of the Brains for Dementia Research Project. Other tissues were provided by the Manchester Brain Bank which is also supported by a grant from the Alzheimer's Society and Alzheimer's Research UK, as part of the Brains for Dementia Research Project."