Herbal drug BNO 1016 is safe and effective in the treatment of acute viral rhinosinusitis.

"Declaration of interest: M. Mondigler is employed by Bionorica SE. P. Stierna and C. Bachert act as scientific consultants for Bionorica SE. H. Stammer is Managing Director of the CRO in charge of operations of the clinical trials. R. Jund was coordinating investigator of the multicenter clinical trials according to §40 German Drug Law. Declaration of interest:"

"The authors thank Bionorica SE, Neumarkt, Germany, for financial support and the investigators at the study centers for recruiting and monitoring the patients in compliance with the study protocol and Good Clinical Practice. The authors are also grateful to the patients for their participation and compliance with the study protocol. The project and data management was conducted by the independent contract research organization Pharmalog Institute for Clinical Research, Munich, Germany."