Antibody engineering for increased potency, breadth and half-life.

"Conflicts of interest A.P. West and P.J. Bjorkman have patent applications pending on improving CD4-binding site antibodies. The remaining authors have no conflicts of interest. A.P. West and P.J. Bjorkman have patent applications pending on improving CD4 - binding site antibodies. The remaining authors have no conflicts of interest."

"Financial support and sponsorship This work was supported by a Collaboration for AIDS Vaccine Discovery (CAVD) grant from the Bill and Melinda Gates Foundation (Grant ID: 1040753 to P.J.B.), National Institutes of Health grant HIVRAD P01 AI100148 (P.J.B.) and award number DP1OD006961 (to P.J.B.), the American Cancer Society (Grant PF-13-076-01-MPC to L.S.), California HIV/AIDS Research Program (CHRP grant F12-CT-214 to S.A.S.)."