Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation.

Authors:
Böser P; Seemann D; Liguori MJ; Fan L; Huang L and 3 more

Journal:
AAPS J

Publication Year: 2015

DOI:
10.1208/s12248-015-9770-4

PMCID:
PMC4476998

PMID:
25896304

Journal Information

Full Title: AAPS J

Abbreviation: AAPS J

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Drug Therapy

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
0.0% Transparent
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Core Indicators
Evidence found in paper:

"the data discussed in this publication have been deposited in ncbi's gene expression omnibus ( ) and are accessible through geo series accession number gse63200 ( http://www ncbi nlm nih gov/geo/query/acc cgi?"

Code Sharing
Evidence found in paper:

"Conflict of Interest This study was funded by AbbVie and AbbVie supported the study design, research, data collection, analysis and interpretation of data, as well as writing, reviewing, and approving the publication. P.B., D.S., M.J.L., L.F., L.H., A.P., and B.K.M. are AbbVie employees and may own AbbVie stocks/options. B.K.M. and A.P. have submitted several patent applications describing antibodies targeting RGMc/hemojuvelin. M.H. is P.B.’s doctoral adviser and an employee at the Mannheim University of Applied Sciences and has no conflicts of interest to report."

Evidence found in paper:

"Conflict of InterestThis study was funded by AbbVie and AbbVie supported the study design, research, data collection, analysis and interpretation of data, as well as writing, reviewing, and approving the publication. P.B., D.S., M.J.L., L.F., L.H., A.P., and B.K.M. are AbbVie employees and may own AbbVie stocks/options. B.K.M. and A.P. have submitted several patent applications describing antibodies targeting RGMc/hemojuvelin. M.H. is P.B.’s doctoral adviser and an employee at the Mannheim University of Applied Sciences and has no conflicts of interest to report."

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Open Access
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Last Updated: Aug 05, 2025