Splicing: is there an alternative contribution to Parkinson's disease?

"snca-007 - 67 aa lrrk2 1 lrrk2-002 - 1271 aa 2 lrrk2-004 nm_198578 2527 aa 3 lrrk2-005 - 207 aa 4 lrrk2-001 - 521 aa 5 lrrk2-003 - no protein 6 lrrk2-006 - no protein 7 lrrk2-007 - no protein vps35 1 vps35-001 nm_018206 796 aa 2 vps35-002 - 48 aa 3 vps35-011 - no protein 4 vps35-012 - no protein 5 vps35-006 - no protein 6 vps35-003 - no protein 7 vps35-010 - no protein 8 vps35-005 - 47 aa 9 vps35-008 - 41 aa 10 vps35-007 - no protein 11 vps35-004 - no protein gene name ensembl transcript names genbank accession numbers and relative encoded amino acidic protein length of splice variants are reported in the table.; table 2 alternative splice variants of human autosomal recessive pd genes gene name transcript number ensembl name genbank accession number protein length park2 1 park2-004 nm_004562 465 aa 2 park2-005 nm_013987 437 aa 3 park2-006 nm_013988 316 aa 4 park2-001 - 274 aa 5 park2-003 - 274 aa 6 park2-007 - 218 aa 7 park2-201 - 176 aa 8 park2-204 - 87 aa 9 park2-002 - 368 aa 10 park2-202 - 74 aa 11 park2-203 - 201 aa pink1 1 pink1-001 nm_032409 581 aa 2 pink1-002 - no protein 3 pink1-003 - no protein dj1 1 park7-004 - 189 aa 2 park7-002 nm_001123377; nm_007262 189 aa 3 park7-007 - no protein 4 park7-001 - 189 aa 5 park7-003 - 169 aa 6 park7-008 - no protein 7 park7-005 - 189 aa 8 park7-006 - 189 aa 9 park7-009 - no protein 10 park7-010 - 160 aa atp13a2 1 atp13a2-001 nm_022089 1180 aa 2 atp13a2-002 nm_001141974 1158 aa 3 atp13a2-005 nm_001141973 1175 aa 4 atp13a2-004 - no protein 5 atp13a2-003 - no protein 6 atp13a2-010 - 191 aa 7 atp13a2-007 - 398 aa 8 atp13a2-014 - 258 aa 9 atp13a2-009 - 321 aa 10 atp13a2-006 - no protein 11 atp13a2-201 - 228 aa 12 atp13a2-013 - no protein 13 atp13a2-011 - 190 aa 14 atp13a2-012 - 191 aa 15 atp13a2-008 - 188 aa pla2g6 1 pla2g6-001 nm_003560 806 aa 2 pla2g6-201 nm_001004426 752 aa 3 pla2g6-002 nm_001199562 752 aa 4 pla2g6-025 - no protein 5 pla2g6-021 - no protein 6 pla2g6-014 - 166 aa 7 pla2g6-024 - no protein 8 pla2g6-013 - no protein 9 pla2g6-026 - 168 aa 10 pla2g6-015 - 120 aa 11 pla2g6-010 - 99 aa 12 pla2g6-023 - 226 aa 13 pla2g6-009 - no protein 14 pla2g6-027 - 51 aa 15 pla2g6-022 - no protein 16 pla2g6-012 - 151 aa 17 pla2g6-019 - 124 aa 18 pla2g6-011 - no protein 19 pla2g6-020 - no protein 20 pla2g6-008 - no protein 21 pla2g6-016 - 229 aa 22 pla2g6-005 - 99 aa 23 pla2g6-018 - 157 aa 24 pla2g6-003 - 99 aa 25 pla2g6-017 - 197 aa 26 pla2g6-007 - 80 aa 27 pla2g6-004 - no protein 28 pla2g6-006 - no protein fbxo7 1 fbxo7-003 - 41 aa 2 fbxo7-001 nm_012179 522 aa 3 fbxo7-004 - 49 aa 4 fbxo7-005 - no protein 5 fbxo7-006 - 129 aa 6 fbxo7-002 nm_001033024; nm_001257990 408 aa 7 fbxo7-007 - 54 aa 8 fbxo7-008 - no protein 9 fbxo7-010 - no protein gene name ensembl transcript names genbank accession numbers and relative encoded amino acidic protein length of splice variants are reported in the table.; table 3 alternative splice variants of human x-linked pd genes gene name transcript number ensembl name genbank accession number protein length taf1 1 taf1-201 nm_001286074 1895 aa 2 taf1-009 nm_138923 1872 aa 3 taf1-008 nm_004606 1893 aa 4 taf1-014 - 458 aa 5 taf1-010 - 490 aa 6 taf1-021 - no protein 7 taf1-011 - no protein 8 taf1-013 - no protein 9 taf1-012 - no protein 10 taf1-015 - no protein 11 taf1-018 - no protein 12 taf1-016 - no protein 13 taf1-022 - no protein 14 taf1-023 - no protein 15 taf1-005 - no protein 16 taf1-006 - no protein 17 taf1-020 - no protein 18 taf1-019 - no protein 19 taf1-017 - 279 aa 20 taf1-007 - 150 aa atp6ap2 1 atp6ap2-004 nm_005765 350 aa 2 atp6ap2-007 - 203 aa 3 atp6ap2-005 - no protein 4 atp6ap2-006 - 243 aa 5 atp6ap2-001 - 259 aa 6 atp6ap2-003 - no protein 7 atp6ap2-002 - no protein gene name ensembl transcript names genbank accession numbers and relative encoded amino acidic protein length of splice variants are reported in the table.; mapt-012 - no protein srrm2 1 srrm2-001 nm_016333 2752 aa 2 srrm2-201 - 311aa 3 srrm2-003 - 1018 aa 4 srrm2-006 - 297 aa 5 srrm2-004 - no protein 6 srrm2-007 - 895 aa 7 srrm2-011 - no protein 8 srrm2-028 - 94 aa 9 srrm2-012 - 115 aa 10 srrm2-013 - 251 aa 11 srrm2-029 - no protein 12 srrm2-014 - no protein 13 srrm2-030 - no protein 14 srrm2-015 - no protein 15 srrm2-016 - no protein 16 srrm2-017 - no protein 17 srrm2-009 - no protein 18 srrm2-018 - no protein 19 srrm2-019 - no protein 20 srrm2-022 - no protein 21 srrm2-020 - 184 aa 22 srrm2-021 - no protein 23 srrm2-023 - no protein 24 srrm2-024 - no protein 25 srrm2-025 - no protein 26 srrm2-026 - no protein 27 srrm2-010 - no protein 28 srrm2-027 - no protein 29 srrm2-031 - 78 aa 30 srrm2-032 - 41 aa 31 srrm2-033 - no protein gene name ensembl transcript names genbank accession numbers and relative encoded amino acidic protein length of splice variants are reported in the table."

"This study was supported by the international Ph.D. program in Neuroscience of the University of Catania. We also gratefully acknowledge Cristina Calì, Alfia Corsino, Maria Patrizia D’Angelo, and Francesco Marino for their administrative and technical support."