Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.

"the rma was re-analysed after these two cases were removed and principal components analysis was performed on the significant differentially expressed genes (the expression dataset is freely available at gene expression omnibus accession number gse66333 ).; au arbitrary units2015 british neuropathological society as cholesterol plays a key role in synapse formation and function [26] the study was extended to assess csf levels of 24(s)-ohc across all braak and braak stages in all available csf samples from one well-characterized centre of the cfas cohort [6] ."

"Disclosure All authors have seen and approved the paper. There are no conflicts of interest specific to this paper."

"This study was supported by the Medical Research Council (MRJ004308/1). C. G. is supported by ARUK (ART:PG2010‐5). CFAS study is supported by the Department of Health and the Medical Research Council (grants MRC/G9901400 and MRC U.1052.00.0013); the UK NIHR Biomedical Research Centre for Ageing and Age‐related Disease Award to the Newcastle upon Tyne Hospitals Foundation Trust; the Cambridge Brain Bank is supported by the NIHR Cambridge Biomedical Research Centre; The Cambridgeshire and Peterborough NIHR CLAHRC; Nottingham University Hospitals NHS Trust; University of Sheffield and the Sheffield Teaching Hospitals NHS Foundation Trust; The Thomas Willis Oxford Brain Collection, supported by the Oxford Biomedical Research Centre; The Walton Centre NHS Foundation Trust, Liverpool. We would like to acknowledge the essential contribution of the liaison officers, the general practitioners, their staff, and nursing and residential home staff. We are grateful to our respondents and their families for their generous gift to medical research, which has made this study possible."