Disruptions in a cluster of computationally identified enhancers near FOXC1 and GMDS may influence brain development.

"We would like to thank Nir Oksenberg for the help in imaging mouse embryos, Caroline Miller for histology services with mouse brain sections, Sean Thomas for sharing predictions of genome-wide locations of transcription factor binding sites, Julie Siegenthaler for providing a foxc1-lacZ embryo, and Kate Lovero for helpful discussion. Funding was provided by grants from the National Heart, Lung, and Blood Institute (NHLBI) (#HL098179), a University of California Achievement Awards for College Scientists (ARCS) Scholarship, a T32 training grant to the UCSF Pediatric Endocrinology Department (#5T32DK007161-41), a gift from the San Simeon Fund, and institutional funds from the J. David Gladstone Institutes. Transgenic mice were generated by Cyagen Biosciences, Inc."