Prehospital Blood Product Resuscitation for Trauma: A Systematic Review.

"No financial support was received in relation to this study. IS and MJM are investigators for the RePHILL Trial, funded by NIHR EME Project grant 14/152/14."

"The study was registered with PROSPERO (CRD42014013794), was conducted according to the published protocol (), and is reported according to PRISMA guidelines () (Checklist, Supplementary Digital Content 1). Relevant studies were sought from bibliographic databases (monthly searches to July 2015) and other relevant sources; see protocol () for full details and Medline search strategy (see also Text, Supplementary Digital Content 2, EMBASE search strategy, at). Standard systematic review methodology aimed at minimizing bias was used for study selection and data extraction. Studies were eligible if they evaluated blood products (case-series) or compared these to other resuscitative fluids (controlled studies); were in patients aged ≥16 years with traumatic haemorrhage; and were conducted in a military or civilian setting. There was no restriction by outcome. Data not included in published manuscripts or abstracts were sought from the relevant authors. Methods:: Bibliographic databases and other sources were searched to July 2015 using keywords and index terms related to the intervention, setting, and condition. Standard systematic review methodology aimed at minimizing bias was used for study selection, data extraction, and quality assessment (protocol registration PROSPERO: CRD42014013794). Synthesis was mainly narrative with random effects model meta-analysis limited to mortality outcomes."