HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.
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Full Title: Biochem Pharmacol
Abbreviation: Biochem Pharmacol
Country: Unknown
Publisher: Unknown
Language: N/A
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"We thank Sophie Bos (Department of Molecular Pharmacology, University of Groningen) for her assistance with preparing mouse precision-cut lung slices. This research was financially supported by the European Research Council with an ERC starting grant (309782) to FJD. Further support was obtained from the Netherlands Organization of Scientific Research (NWO) by a VIDI grant to FJD (723.012.005). We acknowledge COST action ‘epigenetics from bench to bedside (TD0905)’ and ‘epigenetic chemical biology (CM1406)’ for building a European network on epigenetics. Microscopic fluorescence imaging was performed at the UMCG Imaging and Microscopy Center (UMIC), which is supported by NWO-grants 40-00506-98-9021 (TissueFaxs) and 175-010-2009-023 (Zeiss 2p)."
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Last Updated: Aug 05, 2025