Metabolic changes may precede proteostatic dysfunction in a Drosophila model of amyloid beta peptide toxicity.

"Disclosure statement The authors have no actual or potential conflicts of interest."

"Damian C. Crowther was supported by the Wellcome Trust (grant code: 082604/2/07/Z) and an Alzheimer's Research UK Senior Research Fellowship (grant code: ART-SRF2010-2). Stanislav Ott was funded by a BBSRC studentship as part of the BBSRC Research in Ageing PhD programme. The authors would also like to thank Dr Jules Griffin (University of Cambridge, Department of Biochemistry) for help and advice on metabolomics, Flemming Hofmann Larsen, and Søren Balling Engelsen (University of Copenhagen, Department of Food Science) for the use of their 600 MHz spectrometer and Drs Maria Giannakou (University of Cambridge, Department of Zoology) and Beinan Liu (University of Cambridge, Department of Genetics) for helpful discussions. Thanks to Dr Iain Chessell, MedImmune for supporting the drafting of the article."