Variation in Patient Profiles and Outcomes in US and Non-US Subgroups of the Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition (CHAMPION) PHOENIX Trial.

"Disclosures The CHAMPION-PHOENIX trial was funded by The Medicines Company. Dr Harrington discloses the following relationships—Advisory Board: Evidint, Regado, Scanadu; Honoraria: Amgen, Daiichi-Lilly, Gilead Sciences Inc, Janssen R&D, Medtronic, Merck, Novartis Corporation, The Medicines Company, Vida Health, Vox Media, WebMD; Other: American Heart Association; Research Funding: AstraZeneca, Bristol-Myers Squibb, CSL Behring, GSK, Merck, Portola, Sanofi-aventis, The Medicines Company; Ownership Interest: Element Science, MyoKardia. Dr Steg discloses the following relationships—Research Funding (to INSERM U1148): Sanofi, Servier; Speaking or Consultant Fees: Amarin, AstraZeneca, Bayer, Boehringer-Ingelheim, Bristol-Myers Squibb, CSL-Behring, Daiichi-Sankyo, GlaxoSmithKline, Janssen, Lilly, Novartis, Pfizer, Regeneron, Roche, Sanofi, Servier, The Medicines Company; Stock Ownership: Aterovax. Dr Gibson discloses the following relationships—Honoraria: The Medicines Company. Dr Hamm discloses the following relationships—Honoraria: AstraZeneca, Sanofi Aventis, Lilly; Research Funding: Astra Zeneca, The Medicines Company. Dr Price discloses the following relationships—Honoraria: AstraZeneca, Merck & Co, Accriva Diagnostics, The Medicines Company. Dr Prats discloses the following relationships—Employment: The Medicines Company. Dr Deliargyris discloses the following relationships—Employment: The Medicines Company. Dr Mahaffey discloses the following relationships—Honoraria: Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Cubist, Eli Lilly, Epson, Forest, Glaxo Smith Kline, Johnson & Johnson, Medtronic, Merck, Mt. Sinai, Myokardia, Omthera, Portola, Purdue Pharma, Spring Publishing, Vindico, WebMD; Research Funding: Daiichi, Johnson & Johnson, Medtronic, St Jude, Tenax. Dr White discloses the following relationships—Honoraria: AstraZeneca; Research Funding: Sanofi-Aventis, Eli Lilly, National Health Institute, Glaxo Smith Kline, Merck Sharpe & Dohme, AstraZeneca. Dr Bhatt discloses the following relationships—Advisory Board: Cardax, Elsevier Practice Update Cardiology, Medscape Cardiology, Regado Biosciences; Board of Directors: Boston VA Research Institute, Society of Cardiovascular Patient Care; Chair: American Heart Association Quality Oversight Committee; Data Monitoring Committees: Duke Clinical Research Institute, Harvard Clinical Research Institute, Mayo Clinic, Population Health Research Institute; Honoraria: American College of Cardiology (Senior Associate Editor, Clinical Trials and News, ACC.org), Belvoir Publications (Editor in Chief, Harvard Heart Letter), Duke Clinical Research Institute (clinical trial steering committees), Harvard Clinical Research Institute (clinical trial steering committee), HMP Communications (Editor in Chief, Journal of Invasive Cardiology), Journal of the American College of Cardiology (Guest Editor; Associate Editor), Population Health Research Institute (clinical trial steering committee), Slack Publications (Chief Medical Editor, Cardiology Today’s Intervention), Society of Cardiovascular Patient Care (Secretary/Treasurer), WebMD (CME steering committees); Other: Clinical Cardiology (Deputy Editor), NCDR-ACTION Registry Steering Committee (Vice-Chair), VA CART Research and Publications Committee (Chair); Research Funding: Amarin, AstraZeneca, Bristol-Myers Squibb, Eisai, Ethicon, Forest Laboratories, Ischemix, Medtronic, Pfizer, Roche, Sanofi Aventis, The Medicines Company (including for his role as Co-Chair of CHAMPION PHOENIX); Royalties: Elsevier (Editor, Cardiovascular Intervention: A Companion to Braunwald’s Heart Disease); Site Co-Investigator: Biotronik, Boston Scientific, St Jude Medical; Trustee: American College of Cardiology; Unfunded Research: FlowCo, PLx Pharma, Takeda. All other authors have reported that they have no other relationships relevant to the contents of this article to disclose."

"We thank Steven E. Elkin, MS, and Debra Bernstein, PhD, of The Medicines Company for their statistical support, along with Yuyin Liu, MS, and Lanyu Lei, MS, of the Harvard Clinical Research Institute for their independent verification of the analyses. Harvard Clinical Research Institute received funding from The Medicines Company for these analyses. The CHAMPION-PHOENIX trial was funded by The Medicines Company. Dr Harrington discloses the following relationships—Advisory Board: Evidint, Regado, Scanadu; Honoraria: Amgen, Daiichi-Lilly, Gilead Sciences Inc, Janssen R&D, Medtronic, Merck, Novartis Corporation, The Medicines Company, Vida Health, Vox Media, WebMD; Other: American Heart Association; Research Funding: AstraZeneca, Bristol-Myers Squibb, CSL Behring, GSK, Merck, Portola, Sanofi-aventis, The Medicines Company; Ownership Interest: Element Science, MyoKardia. Dr Steg discloses the following relationships—Research Funding (to INSERM U1148): Sanofi, Servier; Speaking or Consultant Fees: Amarin, AstraZeneca, Bayer, Boehringer-Ingelheim, Bristol-Myers Squibb, CSL-Behring, Daiichi-Sankyo, GlaxoSmithKline, Janssen, Lilly, Novartis, Pfizer, Regeneron, Roche, Sanofi, Servier, The Medicines Company; Stock Ownership: Aterovax. Dr Gibson discloses the following relationships—Honoraria: The Medicines Company. Dr Hamm discloses the following relationships—Honoraria: AstraZeneca, Sanofi Aventis, Lilly; Research Funding: Astra Zeneca, The Medicines Company. Dr Price discloses the following relationships—Honoraria: AstraZeneca, Merck & Co, Accriva Diagnostics, The Medicines Company. Dr Prats discloses the following relationships—Employment: The Medicines Company. Dr Deliargyris discloses the following relationships—Employment: The Medicines Company. Dr Mahaffey discloses the following relationships—Honoraria: Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Cubist, Eli Lilly, Epson, Forest, Glaxo Smith Kline, Johnson & Johnson, Medtronic, Merck, Mt. Sinai, Myokardia, Omthera, Portola, Purdue Pharma, Spring Publishing, Vindico, WebMD; Research Funding: Daiichi, Johnson & Johnson, Medtronic, St Jude, Tenax. Dr White discloses the following relationships—Honoraria: AstraZeneca; Research Funding: Sanofi-Aventis, Eli Lilly, National Health Institute, Glaxo Smith Kline, Merck Sharpe & Dohme, AstraZeneca. Dr Bhatt discloses the following relationships—Advisory Board: Cardax, Elsevier Practice Update Cardiology, Medscape Cardiology, Regado Biosciences; Board of Directors: Boston VA Research Institute, Society of Cardiovascular Patient Care; Chair: American Heart Association Quality Oversight Committee; Data Monitoring Committees: Duke Clinical Research Institute, Harvard Clinical Research Institute, Mayo Clinic, Population Health Research Institute; Honoraria: American College of Cardiology (Senior Associate Editor, Clinical Trials and News, ACC.org), Belvoir Publications (Editor in Chief, Harvard Heart Letter), Duke Clinical Research Institute (clinical trial steering committees), Harvard Clinical Research Institute (clinical trial steering committee), HMP Communications (Editor in Chief, Journal of Invasive Cardiology), Journal of the American College of Cardiology (Guest Editor; Associate Editor), Population Health Research Institute (clinical trial steering committee), Slack Publications (Chief Medical Editor, Cardiology Today’s Intervention), Society of Cardiovascular Patient Care (Secretary/Treasurer), WebMD (CME steering committees); Other: Clinical Cardiology (Deputy Editor), NCDR-ACTION Registry Steering Committee (Vice-Chair), VA CART Research and Publications Committee (Chair); Research Funding: Amarin, AstraZeneca, Bristol-Myers Squibb, Eisai, Ethicon, Forest Laboratories, Ischemix, Medtronic, Pfizer, Roche, Sanofi Aventis, The Medicines Company (including for his role as Co-Chair of CHAMPION PHOENIX); Royalties: Elsevier (Editor, Cardiovascular Intervention: A Companion to Braunwald’s Heart Disease); Site Co-Investigator: Biotronik, Boston Scientific, St Jude Medical; Trustee: American College of Cardiology; Unfunded Research: FlowCo, PLx Pharma, Takeda. All other authors have reported that they have no other relationships relevant to the contents of this article to disclose."

"Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01156571."