Role of the host restriction factor APOBEC3 on papillomavirus evolution.

"first in order to determine a single observed vs expected (o/e) dinucleotide ratio across the entire viral genome a custom python script was used (available from a public computer code repository [ http://www github com/van-doorslaer/warren-et-al ])."

"Conflict of interest: None declared"

"This work was supported by National Institutes of Health (R01 AI091968) to D.P. and (R01 CA117907-07) to J.M.E., the Intramural Research Program of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health to K.V.D., and the Cancer League of Colorado to D.P. We thank Katerina Kechris for consultation on statistical analyses. We also thank Paul Lambert, Paul Ahlquist, Mario Santiago, Matt Daugherty, Rob DeSalle, and members of our lab for useful comments and suggestions."