Microinfarcts in an older population-representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease.

"This study was undertaken with ethical approval from a UK Multicentre Research Ethical Committee. CFAS was supported by Department of Health and Medical Research Council grants (MRC/G9901400 and MRC U.1052.00.0013). The MRC (MRC/G0900582) funded this study. Work in the individual CFAS centres in this study is also supported by: UKNIHR Biomedical Research Centre for Ageing and Age‐related Disease Award to the Newcastle upon Tyne Hospitals Foundation Trust; the NIHR Cambridge Biomedical Research Centre (Cambridge Brain Bank) and The Cambridgeshire and Peterborough NIHR CLAHRC; Nottingham University Hospitals NHS Trust; University of Sheffield and the Sheffield Teaching Hospitals NHS Foundation Trust. We acknowledge the essential contribution of the liaison officers, the general practitioners and their staff, and nursing and residential home staff. We are grateful to our respondents and their families for their generous gift to medical research, which has made this study possible. The authors have no conflicts of interest in relation to this manuscript. PGI conceived and designed the study, and wrote the manuscript; TM carried out the statistical analyses, GF provided the microscopical preparations for review; CB contributed data on dementia status and mobility; SBW designed the protocol for microscopical evaluations and contributed the microinfarct data. All authors reviewed and approved the final manuscript."

"This study was undertaken with ethical approval from a UK Multicentre Research Ethical Committee. CFAS was supported by Department of Health and Medical Research Council grants (MRC/G9901400 and MRC U.1052.00.0013). The MRC (MRC/G0900582) funded this study. Work in the individual CFAS centres in this study is also supported by: UKNIHR Biomedical Research Centre for Ageing and Age‐related Disease Award to the Newcastle upon Tyne Hospitals Foundation Trust; the NIHR Cambridge Biomedical Research Centre (Cambridge Brain Bank) and The Cambridgeshire and Peterborough NIHR CLAHRC; Nottingham University Hospitals NHS Trust; University of Sheffield and the Sheffield Teaching Hospitals NHS Foundation Trust. We acknowledge the essential contribution of the liaison officers, the general practitioners and their staff, and nursing and residential home staff. We are grateful to our respondents and their families for their generous gift to medical research, which has made this study possible. The authors have no conflicts of interest in relation to this manuscript. PGI conceived and designed the study, and wrote the manuscript; TM carried out the statistical analyses, GF provided the microscopical preparations for review; CB contributed data on dementia status and mobility; SBW designed the protocol for microscopical evaluations and contributed the microinfarct data. All authors reviewed and approved the final manuscript."