Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

"Disclosure statement Edward T. Bullmore is employed half-time by GlaxoSmithKline, holds shares in GlaxoSmithKline, and is a deputy editor of Biological Psychiatry. Boyd C.P. Ghosh has received honoria from UCB Pharm and GlaxoSmithKline."

"The authors are grateful for computational resources provided by Camgrid (www.ucs.cam.ac.uk/scientific/camgrid). This work was supported by grants from the Medical Research Council (G1100464 to Timothy Rittman, MR/K020706/1 to Petra E. Vértes, and G0700503 to Boyd C.P. Ghosh), the Wellcome Trust (103838 to James B. Rowe), the NIHR-Cambridge Biomedical Research Centre and the Beverley Sackler fellowship scheme (Timothy Rittman and Boyd C.P. Ghosh). Mika Rubinov is supported by a NARSAD Young Investigator Award and the Isaac Newton Trust. The Behavioural and Clinical Neuroscience Institute is supported by a joint award from the Wellcome Trust and Medical Research Council."