CodonShuffle: a tool for generating and analyzing synonymously mutated sequences.

"data availability this software and associated data can be accessed anonymously at https://github com/lauringlab/codonshuffle conflict of interest : none declared."

"complete instructions for software download installation and usage are provided in an open-access github repository https://github com/lauringlab/codonshuffle with recent advances in synthetic biology it is now feasible to generate highly mutated viral genomes in a reasonable time frame ( ).; we have implemented codonshuffle in python and have its component scripts in a github repository that can be accessed anonymously https://github com/lauringlab/codonshuffle .; data availability this software and associated data can be accessed anonymously at https://github com/lauringlab/codonshuffle conflict of interest : none declared."

"Conflict of interest : None declared."

"We thank Robert Woods and John ‘JT’ McCrone for helpful discussion. D.M.d.M.J. was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) – Science without borders (248917/2013-7). A.S.L. was supported in part by a Clinician Scientist Development Award from the Doris Duke Charitable Foundation."