Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy.

"Conflict of interest Z.H. is co-inventor of US patents on neovascular-targeted immunoconjugates (ICON) and is co-inventor of two US patent applications on “Factor VII conjugates for selectively treating neovascularization disorders.” W.R. is currently serving as a consultant for Iconic Therapeutics, a startup biotech based on ICON patents. Other authors declare no conflict of interest."

"We thank Dr. Beth Schachter for critical reading and editing, Dr. William Konigsberg at Yale University for providing mouse monoclonal anti-HTF (HTF1) antibody and Dr. Wolfram Ruf at The Scripps Research Institute for kind gifts of CHO-K1 lines stably expressing TF or TF + EPCR, untransfected CHO-K1 cells (as negative control for TF and EPCR) and plasmid encoding EPCR that allowed us to generate stable CHO-K1/EPCR cell lines in this study. This work was supported partly by CT DPH Biomedical Research Grant (RFP#2009-0096), a startup fund (Z.H.) from The Ohio State University College of Medicine and The OSU James Comprehensive Cancer Center (OSUCCC), a Seed Award from the OSUCCC Translational Therapeutics Program and a Phase 1 L-Pilot Award from the OSU Center for Clinical and Translational Science through Award Number UL1TR001070 from the National Center For Advancing Translational Sciences."