Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers.

"The study was entirely sponsored by GE Healthcare (GEHC). Author Heurling was a full-time employee of GE Healthcare when the data were analyzed and the manuscript prepared. Authors Zanette and Sherwin are full-time employees of GE Healthcare. All other authors were compensated for being investigators in the study but declare no other conflicts of interest. Authors Miki, Shimada, Senda, Kim, Yamamoto, Sugino, and Kowa made substantial contributions to the acquisition of data for the work, revising the manuscript critically for important intellectual content, giving final approval of the version to be published, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Authors Zanette, Heurling, and Sherwin were involved in the conception and design of the study, analysis and/or interpretation of the data, drafting and revising the manuscript for important intellectual content, giving final approval of the version to be published, and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. GE employees Christopher J. Buckley PhD and Gillian Farrar PhD reviewed the manuscript and provided helpful comments."

"Funding The study was sponsored entirely by GE Healthcare (GEHC)."

"Trial registration Clinicaltrials.gov registration number NCT02813070."