The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.

"Disclosure statement The authors report no conflict of interest."

"The research team would like to thank the PET imaging technologist, MRI radiographers, technicians, and radiochemists at the Wolfson Brain Imaging Centre for their help in acquiring the neuroimaging data. The authors would also extend their sincere gratitude to all the participants with DS, their families and careers for their time, commitment and support of the Dementia in Down syndrome study conducted at the University of Cambridge. Finally, the recruitment for this study was generously supported by the Down Syndrome Association (UK) and the care organisation Hft. The views expressed are those of authors and not necessarily those of the Medical Research Council, the NIHR, or the Department of Health. This work was supported by the Medical Research Council (grant number: 98480). Additional support was received from the NIHR Cambridge Biomedical Research Centre, the NIHR Collaborations in Leadership for Applied Health Research and Care (CLAHRC) for the East of England, the NIHR Cambridge Dementia Biomedical Research Unit, the Down Syndrome Association and the Health Foundation."