Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73 to 76.

"Disclosure statement The authors declare no potential conflicts of interest."

"The authors thank the LBC1936 participants and radiographers at the Brain Research Imaging Centre, the nurses of the Wellcome Trust Clinical Research Facility, Edinburgh, members of the LBC1936 research team for coordination, data collection, and entry, and the staff at Lothian Health Board. We thank the Scottish Council for Research in Education for access to the Scottish Mental Survey data. This work was supported by a Research into Ageing programme grant (I. J. D. and J. M. S.) and the Age UK-funded Disconnected Mind project (I. J. D., J. M. S., and J. M. W.), with additional funding from the UK Medical Research Council (I. J. D., J. M. S., J. M. W., and M. E. B.) under grant numbers G0701120, G1001245, and MR/M013111/1. J. M. W. is supported by the Scottish Funding Council through the SINAPSE Collaboration (http://www.sinapse.ac.uk). M. V. H. is supported by the Row Fogo Charitable Trust (grant number: BRO-D.FID3668413). The work was undertaken within The University of Edinburgh Centre for Clinical Brain Sciences and Centre for Cognitive Aging and Cognitive Epidemiology (http://www.ccace.ed.ac.uk), part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). Funding from the UK Biotechnology and Biological Sciences Research Council and the Medical Research Council are gratefully acknowledged. We thank Paul Redmond for his technical assistance."