Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.

"Disclosure statement The authors have no actual or potential conflicts of interest."

"We would like to thank the PET imaging technologist, MR radiographers, technicians, and radiochemists at the Wolfson Brain Imaging Centre, along with the clinicians for their assistance in acquiring the data reported herein. We would particularly like to thank all participants with Down syndrome, their families and carers for their time and support of this research. James Cole is funded by a research grant to Imperial College London from the Medical Research Council (MR/L022141/1).The collection of the data reported in this paper was supported by a grant to the University of Cambridge from the Medical Research Council (Grant ID # 98480). Additional funding came from the NIHR Cambridge Biomedical Research centre, the NIHR Collaborations in Leadership for Applied Health Research and Care (CLAHRC) for the East of England, the NIHR Cambridge Dementia Biomedical Research Unit, the Down's Syndrome Association (DSA) and the Health Foundation. We are grateful for their support. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health."