Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns.

"The authors report no conflicts of interest."

"RZ was supported by a stipend from the Thrasher Research Fund (TRF13064) and from Tergooi Hospitals, Blaricum, The Netherlands. Funding source: The Thrasher Research Fund (TRF13064) and Tergooi Hospitals, Blaricum, The Netherlands."

"A prospective observational cohort study was performed at the neonatal care facility of the Academic Pediatric Center Suriname at the Academic Hospital Paramaribo. Patients were included in a 14-month period between April 1, 2015 and May 31, 2016. Newborns with a gestational age equal to or above 34 weeks in whom antibiotics were started within the first 72 h of life for suspected EOS were included. Excluded were neonates of whom no serum was obtained or not enough information was available after the study period to confirm outcomes. Written informed consent was obtained from at least one parent for the use of residual serum and clinical information. The study protocol was approved by the Surinamese Medical-Ethical Board (VG-021-14A) and was made available on clinicaltrials.gov (Trial registration: NCT02486783 registered 27/6/2015)."