ApoE influences regional white-matter axonal density loss in Alzheimer's disease.

"Disclosures statement Dr Slattery reports having received personal fees from GE Healthcare. Professor Fox reports personal fees from Janssen/Pfizer, IXICO, Roche, Lilly Research Laboratories (Avid), Novartis Pharma AG, Sanofi and GSK (all fees paid to University College London). The remaining authors declare no conflicts of interest."

"The authors thank all patients and controls for their participation. They also thank Simon Mead and Gary Adamson (MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology) for analyzing the APOE ε4 genotype status of participants, and Timothy Shakespeare, Keir Yong, Aida Suarez Gonzalez, and Silvia Primativo for assistance with neuropsychology assessments. The Dementia Research Centre is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation. This work was supported by the NIHR Queen Square Dementia Biomedical Research Unit and the NIHR UCL/H Biomedical Research Centre. Daniel C. Alexander and Hui Zhang are supported by EPSRC (EP/L022680/1). Sebastian J. Crutch is supported by grants from ESRC/NIHR (ES/L001810/1), EPSRC (EP/M006093/1) and an Alzheimer's Research UK Senior Research Fellowship. David M. Cash is supported by grants from the Alzheimer Society (AS-PG-15-025), Alzheimer's Research UK (ARUK-PG2014-1946) and MRC (MR/M023664/1). Nick C. Fox is a NIHR senior investigator. Marc Modat is supported by the UCL Leonard Wolfson Experimental Neurology Centre (PR/ylr/18575) and receives funding from Alzheimer's Society (AS-PG-15-025). Sebastien Ourselin receives funding from the EPSRC (EP/H046410/1, EP/J020990/1, EP/K005278), the MRC (MR/J01107X/1), the EU-FP7 project VPH-DARE@IT (FP7-ICT-2011-9-601055), the NIHR Biomedical Research Unit (Dementia) at UCL and the National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative- BW.mn.BRC10269). Jonathan M. Schott is supported by EPSRC (EP/J020990/1), MRC (CSUB19166), ARUK (ARUK-Network 2012-6-ICE; ARUK-PG2014-1946), and European Union's Horizon 2020 research and innovation programme (grant 666992). David L. Thomas is supported by the UCL Leonard Wolfson Experimental Neurology Centre (PR/ylr/18575). Jiaying Zhang is supported by China Scholarship Council."