A monoclonal antibody raised against a thermo-stabilised β<sub>1</sub>-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β<sub>1</sub>-adrenoceptors expressed in stable cell lines.
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Full Title: Biochem Pharmacol
Abbreviation: Biochem Pharmacol
Country: Unknown
Publisher: Unknown
Language: N/A
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Evidence found in paper:
"Conflict of interest AB, GC and CJH are shareholders in Heptares Therapeutics (part of the Sosei Group) and hold stock options in the Sosei Group. CJH is a consultant for Heptares Therapeutics. The remaining authors declare no conflict of interest."
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"The work was supported by the Medical Research Council [grant numbers G0800006, MR/N020081/1], Heptares Therapeutics Ltd. and the University of Nottingham for financial support."
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Last Updated: Aug 05, 2025