Baroreflex Sensitivity and Blood Pressure Variability can Help in Understanding the Different Response to Therapy During Acute Phase of Septic Shock.

"The authors report no conflicts of interest."

"This study is supported by the EU FP7 Health Programme, ShockOmics project, Grant #602706."

"The present work is an ancillary study from the multicenter prospective observational trial Shockomics (see ClinicalTrials.gov Identifier NCT02141607). A complete description of the protocol can be found in (). A subset of 21 septic shock patients enrolled at Genève University Hospital from October 2014 till December 2015 was included in this study, after approval of the Geneva regional research ethics committee (Commission cantonale d’éthique de la recherché, President: Prof. Bernhard Hirschel study number 14-041). All participants gave prior informed consent. Strict inclusion criteria were observed during the recruitment phase, as detailed reported in (), to avoid a too high inhomogeneity within the population. The patients received initial therapy according to the standards () immediately after shock diagnosis (time T0). Patients were analyzed at two relevant time points: within 16 h from T0 when the inflammatory cascade has been just activated (T1), and within 48 h after T0 time point (T2)."