Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice.

"Conflicts of interest Development of UE2316 was primarily supported by a Wellcome Trust Seeding Drug Discovery award (to BRW, SPW). SPW and BRW are inventors on relevant patents owned by the University of Edinburgh and licensed to Actinogen Medical Ltd. SPW, and BRW act as paid consultants to Actinogen Medical Ltd."

"We are grateful to the Wellcome Trust and British Heart Foundation (and their Centre or Research Excellence; RG-05-008, BHF RE/08/001) for funding this work and to the staff at the Biomedical Research Facility and the Edinburgh Mass Spectrometry Core Laboratory for scientific support. Conflicts of interestDevelopment of UE2316 was primarily supported by a Wellcome Trust Seeding Drug Discovery award (to BRW, SPW). SPW and BRW are inventors on relevant patents owned by the University of Edinburgh and licensed to Actinogen Medical Ltd. SPW, and BRW act as paid consultants to Actinogen Medical Ltd."