Intradermal immunisation using the TLR3-ligand Poly (I:C) as adjuvant induces mucosal antibody responses and protects against genital HSV-2 infection.

"The authors declare no conflict of interest."

"We thank David Gallouche from the animal core facility (PBES, ENS Lyon, UMS3444) for maintenance of mice, and the mammalian protein expression facility at University of Gothenburg for preparation of gD protein. We thank Raphaelle El Habib for help in obtention of reagents and critical discussions, Feriel Hacini-Rachinel, Morgan Taillardet and Jean-Benoit Le Luduec for excellent technical assistance, and Ludovic Moro-Sibilot for figure editing. This work was supported from INSERM, an FP6 EUROPRIZE grant from EEC and from the High Impact Project ADITEC from FP7. This work was supported by INSERM, an EUROPRIZE FP6 grant from EEC, and the High Impact Project Advanced Immunization Technologies (ADITEC) supported by FP7 grant from EEC."