Intravenous delivery of adeno-associated virus 9-encoded IGF-1Ea propeptide improves post-infarct cardiac remodelling.

"The authors declare no conflict of interest."

"We are grateful to E.L.P.'s group at the CNIC for excellent technical assistance and advice, and to members of the Rosenthal laboratory for critical discussion. We also thank the University of Pennsylvania, Penn Vector Core, for generating AAV9 vectors. This work was supported by grants from the European Unionś Seventh Framework Programme Marie Curie Initial Training Network—CardioNeT GA-289600 to N.R. and E.L.P., and British Heart Foundation grants—RM/13/1/30157 to N.R. E.L.P. was also supported by European Unionś Seventh Framework Programme -CardioNext ITN-608027, CardioNeT-ITN-289600), from the Spanish Ministry of Economy and Competitiveness (SAF2012–31451) and from the Regional Government of Madrid (2010-BMD-2321 ‘Fibroteam’). E.G.C. gratefully acknowledges the support from the BritishSpanish Society (BSS) for the BritishSpanish Society/Santander Universities 2015 fellowship that partially supported this project."