The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues.

"Competing interests V.P.Y., M.A.Z., and K.B.S. are inventors on a patent and related IP pertaining to the use of MSI-1436 to stimulate tissue repair and regeneration. K.B.S. and V.P.Y. are cofounders of Novo Biosciences, Inc., the company that licensed the MSI-1436 Intellectual Property from the MDI Biological Laboratory."

"We thank Chrissy Dykeman, Ari Dehn and Ann-Marie Allen for zebrafish animal care, and MaryLynn FitzSimons, Ken Poss, Nadia Rosenthal and Alejandro Sanchez Alvarado for critical comments on the manuscript. Helen Roberts, Axel Heinemann and Saskia Heinemann provided technical support in the screening of regenerative compounds. This work was supported by Center of Biomedical Research Excellence (COBRE) grant P20 GM104318 and by Institutional Development Award (IDeA) grant P20 GM103423 from the National Institute of General Medical Sciences. Additional support was provided by Maine Technology Institute grants SG5209, SG5348, and an American Heart Association Scientist Development Grant 11SDG7210045 to VPY. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the NIH."