Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated With Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts.

"Disclosures G. Lauc is a founder and owner, I. Gudelj and I. Trbojević-Akmačić are employees of Genos, Ltd, which offers commercial service of glycomic analysis and has 2 patents in this field (WO/2014/203010 and WO/2017/215973). The other authors report no conflicts."

"Sources of Funding This work was funded by the British Heart Foundation (BHF) Special Project grant SP/12/4/29573 and Medical Research Council (MRC)/British Heart Foundation Ancestry and Biological Informative Markers for Stratification of Hypertension (AIMHY; MR/M016560/1) grant. Twins UK receives funding from the Wellcome Trust European Community’s Seventh Framework Programme (FP7/2007–2013 to TwinsUK); the National Institute for Health Research (NIHR) Clinical Research Facility at Guy’s & St Thomas’ National Health Service (NHS) Foundation Trust and NIHR Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. This work also receives funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 603946 (Health and Environment-wide Associations Based on Large population Surveys (HEALS). Glycan analysis was supported by European Commission Framework programme 7 grants Methods for Integrated analysis of Multiple Omics datasets (MIMOmics; contract number 305280), H2020 grants GlySign (contract number 722095), and IMforFuture (contract number 721815), as well as by the European Structural and Investment Funds IRI (grant number KK.01.2.1.01.0003) and Croatian National Centre of Research Excellence in Personalized Healthcare (grant number KK.01.1.1.01.0010). ORCADES (Orkney Complex Disease Study) was supported by the Chief Scientist Office of the Scottish Government (CZB/4/276, CZB/4/710), the Royal Society, the MRC Human Genetics Unit quinquennial programme QTL in Health and Disease, Arthritis Research UK, and the European Union framework program 6 EUROSPAN project (contract number LSHG-CT-2006–018947). T.D. Spector is a National Institute for Health Research Senior Investigator. A.M. Valdes is supported by the NIHR Nottingham British Research Council."