NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.

"Conflict of interest Ryota Hokari received commercial research funding from EA pharma Co. Ltd and Chugai pharma Co. Ltd; Taku Kobayashi received lecture fees from Mitsubishi Tanabe Pharma Corporation, AbbVie Inc., Takeda Pharmaceutical Co. Ltd, and Janssen Pharmaceutical K.K.; Makoto Naganuma received commercial research funding from Mochida Pharmaceuticals Co. Ltd; Masaru Shinozaki received research grants from Mitsubishi Tanabe Pharma Co., Ltd; Shiro Nakamura received a commercial research funding from AbbVie Inc., Kyorin Pharmaceutical Co. Ltd, Mitsubishi Tanabe Pharma Corporation, Astellas Pharma Inc., Asahi Kasei Medical Co. Ltd, Ajinomoto Pharmaceuticals Co. Ltd, Eisai Co. Ltd, JIMRO Co. Ltd, Otsuka Pharmaceutical Co. Ltd, Otsuka Pharmaceutical Factory Inc., UCB Japan Co. Ltd, and Zeria Pharmaceutical Co. Ltd; Hiroshi Nakase received lecture fees from Mitsubishi Tanabe Pharma Corporation, Mochida Pharmaceuticals Co. Ltd, and Janssen Pharmaceutical K.K., and received commercial research funding from Hoya group Pentax Medical, Boehringer Ingelheim GmbH, and Daiichi-Sankyo Co. Ltd; Tadakazu Hisamatsu received lecture fees from EA pharma Co. Ltd, AbbVie GK, Celgene K.K., Janssen Pharmaceutical K.K., Pfizer Inc., Mitsubishi Tanabe Pharma Corporation, Kyorin Pharmaceutical Co. Ltd, JIMRO Co. Mochida Pharmaceutical Co., Ltd Nichi-Iko Pharmaceutical Co., Ltd, and received commercial research funding from Mitsubishi Tanabe Pharma Corporation, EA pharma Co. Ltd, AbbVie GK, Daiichi-Sankyo, Kyorin Pharmaceutical Co. Ltd, Takeda Pharmaceutical Co. Ltd, Pfizer Inc., Mochida Pharmaceutical Co., Ltd; Masao Nagasaki held the concurrent post at Department of Cohort Genome Information Analysis endowed by Toshiba Corporation until March 2017, and received a research funding from Toshiba Corporation until March 2017; Yasuo Suzuki received lecture fees from AbbVie Inc., Kyorin Pharmaceutical Co. Ltd, Mitsubishi Tanabe Pharma Corporation, EA Pharma Co. Ltd, Mochida Pharmaceuticals Co. Ltd, and Zeria Pharmaceutical Co. Ltd; and received commercial research funding from AbbVie Inc., Mitsubishi Tanabe Pharma Corporation, EA Pharma Co. Ltd, JIMRO Co. Ltd, Mochida Pharmaceuticals Co. Ltd, and NIPPON KAYAKU Co. Ltd."

"We would like to thank all of the patients who participated in this study. This research was supported by AMED under Grant Number JP18kk0305002 to Y. Kakuta, and JP16km0405205 to M. Nagasaki. This work was supported in part by the Tohoku Medical Megabank Project (Special Account for Reconstruction from the Great East Japan Earthquake). Some of the computational resources were provided by the ToMMo supercomputer system. Members of MENDEL study group (name and affiliation) are: Shunji Ishihara and Naoki Oshima (Department of Internal Medicine II, Shimane University Faculty of Medicine, Shimane, Japan.), Takehiko Katsurada (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.), Yu Sasaki (Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.), Takafumi Otsuka (Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan.), Mikihiro Fujiya (Department of Medicine, Division of Gastroenterology and Hematology/Oncology, Asahikawa Medical University, Asahikawa, Japan.), Motoyuki Onodera (Department of Gastroenterology, Iwate Prefectural Isawa Hospital, Iwate, Japan.), Masakazu Nagahori and Katsuyoshi Matsuoka (Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.), Katsuhiro Arai (Division of Gastroenterology, National Center for Child Health and Development, Setagaya, Tokyo, Japan.), Yuichiro Sato (Department of Gastroenterology, Osaki Citizen Hospital, Osaki, Japan.), Mitsunori Noguchi (Noguchi Clinic, Sendai, Japan), Minoru Matsuura (Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Japan.), Hisaaki Kudo and Naoko Minegishi (Department of Biobank, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan), Tomoaki Ishikawa, Hiroki Nakajima and Hiroshi Terasaki (LSI Medience Corporation, Japan), Rumiko Saito and Isao Amemiya (Toshiba Corporation, Japan), Izuru Abe, Tomoyuki Handa, Yutaro Masu, Kaoru Suzuki, Kasumi Hishinuma, Takeru Nakano, Yasuhiro Izumiyama, Ryo Ichikawa, Shin Matsumoto, Hiroshi Nagai, Hirofumi Chiba, Naonobu Yokoyama, Katsutoshi Yamamoto, Yusuke Shimoyama, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura and Kenichi Negoro (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan), and Mai Kato (MENDEL study secretariat)."